Responsibilities:
-
Design and develop formulations for preclinical pharmacology, toxicology, and pharmacokinetic (PK) animal studies of innovative chemical drugs (including conventional small molecules, peptides, and TACs), such as suspensions, solutions, solid dispersions, and nanoformulations.
-
Perform comprehensive physicochemical characterization of APIs, including solid-state characterization (polymorph, salt, and co-crystal screening), solubility, stability, powder properties, pKa, LogP/D, etc.
-
Responsible for literature research, formulation screening, process optimization, and scale-up for innovative chemical drug formulation projects.
-
Responsible for conducting studies in compliance with requirements, maintaining original records, organizing, compiling, and archiving documents, and writing research reports and patent-related documents.
-
Responsible for daily use, maintenance, and qualification/validation of relevant instruments and equipment (e.g., pH meter, DSC, TGA, HPLC, etc.).
-
Assist in improving laboratory SOP and other management systems and optimizing workflows.
Qualifications:
(I) Professional Knowledge Requirements:
Background in chemistry, analytical chemistry, or pharmacy; master's degree or above.
-
Able to independently complete early formulation development and optimization for innovative chemical drugs (including poorly soluble drugs and special dosage forms).
-
Proficient in theories and methods of polymorph/salt screening; skilled in operating and using solid-state characterization instruments such as XRPD, TGA, DSC, DVS, PLM, and PSD for data analysis and interpretation.
-
Proficient in using chemical analytical instruments, including LC, GC, KF, NMR, PSD, DSC, TGA, etc.
-
Able to independently complete literature research, formulation screening, process optimization, and scale-up for innovative chemical drug formulation projects.
-
Able to independently conduct studies in compliance with requirements, maintain original records, organize, compile, and archive documents, and write research reports.
-
Able to complete procurement, use, maintenance, and management of relevant daily experimental instruments and equipment.
-
Able to assist in improving laboratory SOP and other management systems and optimizing workflows.
(II) Industry Experience Requirements:
3+ years of experience in preformulation and formulation process development research in innovative drug R&D companies/CROs/CDMOs. Experience in preclinical formulation optimization research is preferred.
(III) Competency Requirements:
Excellent logical thinking, data analysis and problem-solving, and communication and coordination skills; able to handle multiple projects simultaneously, plan schedules reasonably, and deliver on time.
Good English reading and writing skills; able to read English literature and write technical reports proficiently.